The history of Medical College starts with construction of Sree Avittom Thirunal hospital for women and children by Travancore Royal Family. Avittom Thirunal was the crown prince of Travancore. His death due rheumatic heart disease lead then Maharaja Sree Padmanabha dasa chithira thirunal balarama verma to construct this unique first few of its kind in India. In 1948, the government of Travancore appointed a committee to formulate proposals for a medical college at Thiruvananthapuram. The committee submitted its report and the scheme was sanctioned in October of that year. C. O. Karunakaran was appointed Special Officer for the implementation of the scheme, and was the college's first dean.

The campus was 139 acres (0.56 km2), with hillocks surrounded by evergreen coconut groves and paddy fields and facing the sea, 4 kilometres (2.5 mi) from northwestern Thiruvananthapuram city. Its layout and architectural designs were prepared by J. A. Ritchie of Bombay. The college and hospital buildings were separated by playgrounds for football and hockey, a cricket pitch, courts for tennis, basketball, badminton and volleyball, and a 400-meter track.

The foundation stone was laid by Raja Pramukh of Travancore–Cochin (Sree Padmanabhadasa Vanchipala Chithira thirunal Balarama Verma) at 11:45 am on 26 January 1950, and the first group of students was admitted in August 1951. The college was dedicated by Jawaharlal Nehru at 8:00 am on 27 November 1951 in the presence of Sree Chithira Thirunal. In January 1952, the Sri. Avittom Thirunal Hospital (SATH) was dedicated by Rajkumari Amrit Kaur. A men's hostel opened in 1952, followed by a women's Hostel one year later. The Medical College Hospital was dedicated by Prime Minister Nehru in 1954.

The library was established during the 1960s. The limb center and mental and ophthalmic hospitals were brought into the college. During the 1990s the Regional Institute of Ophthalmology was founded. The Sree Chitra Thirunal Centre, the College of Pharmaceutical Sciences and the Priya Darshini Institute of Paramedical Sciences were established, and the Silver Jubilee Auditorium was built.

A specialty block, housing the college's medical and surgical specialties, became operational on 1 July 2010. The block was funded by the prime minister's Swasthya Suraksha Yojna scheme and by the Kerala government. The 253-bed, 160,000-square-foot (15,000 m2) specialty block houses the outpatient clinics and inpatient wards of six specialties, eight operating theatres, six 29-bed intensive-care units and dialysis and kidney-transplant units.

It is financed and administered by the Health and Family welfare Department of the government of Kerala. Although the college was initially affiliated with the University of Kerala, since 2010 it has been affiliated with the Kerala University of Health Sciences..

• GMCT Established 1951
• MCH Established 1952
• SATH Established 1951
• Upgraded to the RIO 1995

In addition to an MBBS programme, postgraduate degree and diploma courses in 22 specialties are offered. Courses offered by the college are: M.B.B.S., M.D.-M.S., D.M.-M.Ch., BSc (Hons.) in Optometry,Bachelor of Pharmacy, BSc (Hons.) in Nursing, BSc (Hons.) in Medical Lab Technology, BSc in Perfusion Technology, BSc in Cardiovascular Technology, BSc in Nursing (post-certificate), MSc in Nursing, Master of Pharmacy, Master of Science in Medical Laboratory Technology, Master of Science in Medical Physics and Epidemiology, M.Phil in Clinical Epidemiology , CENTRAL STERILE SUPPLY TECHNOLOGY- DCSST 2 year diploma course under DME kerala, Diploma in Medical Laboratory Technology, Diploma in Radiological Technology, Diploma in Dialysis Technology, Diploma in General Nursing and Midwifery, Diploma in Clinical Child Development, Diploma in Pharmacy, Dental Mechanics Certificate Course, Diploma in Operation Theatre and Anaesthesia Technology, Diploma in Endoscopy Technology, Diploma in Neurotechnology Diploma in Optometry.

• MBBS
• PG
• MCH
• Praeamedical & Diploma courses

About 4 kilometres (2.5 mi) from the main campus, the Regional Institute of Ophthalmology is near the general hospital in Thiruvananthapuram. It originated as a government ophthalmic hospital in 1905, and was brought into the National Programme for Control of Blindness in 1995. The RIO is directed by Dr Sahasranamam V. Postgraduate courses in ophthalmology are offered, and a bachelor's-degree course in optometry is available with an annual intake of 20 students. A BSc. Optometry course began in 2010.

RIO is India's second government institute offering a bachelor's degree in optometry. It hosts an optical outlet (in collaboration with HLL Life Care) and a dispensing facility. Specialized services including retina, paediatric ophthalmology, low vision, cornea and glaucoma clinics, an eye bank, tele-ophthalmology, a uvea clinic, a dispensing lab and contact-lens and cataract clinics. Kerala's first mobile eye hospital, Sunayanam, operates from the RIO.

The School of Optometry is on the RIO campus. A Bachelor of Science (Honours) degree in optometry is affiliated with Kerala University of Health Sciences. GMC Thiruvananthapuram is India's second government institute offering a four-year professional degree course in optometry

The women's and children's hospital was dedicated in 1952. It was built by the Travancore royal family in memory of Prince Sree Avittom Thirunal, who died at age eight years of rheumatic heart disease. The hospital houses the departments of obstetrics and gynecology and pediatrics. The OB-GYN department administers the postpartum, family-welfare counseling, infertility, trophoblastic, adolescent and vesicular-mole clinics and WHO and Indian Council of Medical Research collaborative study centers. The hospital also provides pediatric care in cardiology, neurology, nephrology, genetics, surgery and psychiatry, and has one of Asia's highest delivery rates.

• Pediatrics
• Obstetrics and Gynecology
• Reproductive Medicine
• Emergency Services
• Pediatric Cardiology
• Pediatric Neurology
• Pediatric Nephrology
• Pediatric Genetics
• Pediatric Surgery
• Behavior Pediatrics
• Neonatology
• Pediatric Gastroenterology 

  This is the first time that a multi-speciality block Chief Minister Pinarayi Vijayan will inaugurate a multi-specialty block (MSB) at Government Medical College Hospital (MCH) here on Thursday. The block will house the sophisticated intensive care units of various medical specialities and it will have 102 ICU beds with ventilator facilities and 44 high-care beds. The building has two levels below the ground, where one floor has been devoted to parking facilities, electrical station, pumping room, oxygen plant, maintenance room and a dining room for visitors to the hospital.

   The PMR department is located about 100 metres from the medical college main gate on the Medical College junction - Kumarapuram road adjacent to medical college post office. The department offers both out patient (OP) and in patient (IP) rehabilitation. Neurological, Musculoskeletal and Rheumatological cases across pediatric to geriatric age groups form the bulk of cases attending here. The department offers comprehensive rehabilitation services including physiatry, rehab nursing, physiotherapy, occupational therapy, orthotics, prosthetics, social rehab etc. The department conducts specific clinics for cerebral palsy, sports injury, obesity, stroke and also weekly outreach clinic at Pangappara Medical College unit. Also it provides 3 year post graduation course in PMR (MD PMR) for qualified MBBS graduates. accumsan dui gravida. Vivamus ut dui eu arcu hendrerit ultricies.